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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL3
All Species:
36.06
Human Site:
Y376
Identified Species:
52.89
UniProt:
Q13618
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13618
NP_003581.1
768
88930
Y376
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Chimpanzee
Pan troglodytes
XP_001167451
757
87889
Y365
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Rhesus Macaque
Macaca mulatta
XP_001109600
746
86448
Y354
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Dog
Lupus familis
XP_534586
746
86477
Y354
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLV5
768
88930
Y376
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Rat
Rattus norvegicus
Q9JJ31
780
90872
Y373
L
T
A
R
D
K
A
Y
K
A
V
V
N
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512511
642
74121
L270
S
L
F
I
D
D
K
L
K
K
G
V
K
G
L
Chicken
Gallus gallus
XP_422620
768
88957
Y376
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Frog
Xenopus laevis
Q6DE95
768
88933
Y376
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Zebra Danio
Brachydanio rerio
NP_955985
766
89011
Y374
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
A398
F
V
A
A
L
D
K
A
C
G
K
F
I
N
S
Honey Bee
Apis mellifera
XP_625079
767
89385
E373
Q
M
I
A
S
D
F
E
Y
F
L
N
L
N
T
Nematode Worm
Caenorhab. elegans
Q17391
777
90217
T382
R
F
Q
H
D
F
E
T
F
L
N
S
N
R
Q
Sea Urchin
Strong. purpuratus
XP_001178314
675
78472
T303
E
Y
F
L
N
L
N
T
K
S
P
E
Y
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
F363
C
F
Q
N
H
T
L
F
H
K
A
L
K
E
A
Baker's Yeast
Sacchar. cerevisiae
P53202
744
86097
R356
S
I
D
F
G
S
V
R
L
N
N
L
T
G
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.1
96.8
N.A.
99.4
26.4
N.A.
83.1
99.6
98.5
95.9
N.A.
28.4
77.2
49.6
67
Protein Similarity:
100
98
97.1
96.8
N.A.
99.6
49.4
N.A.
83.3
99.7
99.2
98.3
N.A.
52.4
87.5
69.1
76.9
P-Site Identity:
100
100
100
100
N.A.
100
26.6
N.A.
6.6
100
100
100
N.A.
6.6
0
46.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
33.3
100
100
100
N.A.
26.6
20
53.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
26.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.5
46.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
63
13
0
0
7
7
0
7
7
0
0
0
13
% A
% Cys:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
69
19
0
0
0
0
0
0
0
7
7
% D
% Glu:
7
0
0
0
0
0
57
7
0
0
0
7
0
7
0
% E
% Phe:
7
13
13
7
0
57
7
7
57
7
0
7
0
0
0
% F
% Gly:
0
0
0
50
7
0
0
0
0
7
7
0
0
13
0
% G
% His:
0
0
0
7
7
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
57
7
7
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
0
7
13
0
19
13
7
0
13
0
0
% K
% Leu:
7
7
0
7
7
7
7
7
7
57
7
63
7
7
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
7
0
0
7
63
7
63
13
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
7
0
13
0
0
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
7
0
0
7
0
0
0
7
0
0
0
0
0
7
50
% R
% Ser:
13
0
0
0
7
7
0
0
0
7
0
7
0
50
13
% S
% Thr:
50
7
0
0
0
7
0
13
0
0
0
0
7
0
7
% T
% Val:
0
7
0
0
0
0
7
0
0
0
7
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
57
7
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _